Alternative PolyAdenylation (APA) is an important post-transcriptional regulatory mechanism that recognizes different polyadenylation signals on transcripts, resulting in transcripts with different lengths of 3’ untranslated regions, thereby influencing a series of biological processes. Recent studies have highlighted the important roles of APA in human and model animals. However, the scope for gene regulation at the level of cleavage and polyadenylation in other animals has not been fully recognized, and there is no database that provides comprehensive APA information for other animals. Therefore, we constructed the animal APA database (Animal-APAdb).

In Animal-APAdb, we systematically characterized APA profiles in 9244 samples of 18 species using RNA sequencing data collected from public databases. In addition, we predicted the polyadenylation sites (PAS) and identified motifs near PAS (APA motifs) of these species. These APA events in different tissues of different species may be useful for uncovering novel mechanisms of animal transcription regulation, development of tissues and phenotypes.